UJI AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK ETANOL 70% Echinometra mathaei PADA TIKUS PUTIH JANTAN GALUR WISTAR YANG DIINDUKSI ALOKSAN

Abstract : Sea urchin (Echinometra mathaei) contains a compound of Echinochrome A, which is polyhydroxy naphthoquinone that known to be potential antioxidant. The antioxidant effect correlated with the antidiabetic activity associated oxidative stress conditions. aim this study was determine 70% Ethanol Extract sea on blood glucose levels in alloxan induced rats. This research an experimental using 30 male white rats, divided into 6 groups, i.e negative control group (normal rat were only given CMC Na 0,5%), Positive (hyperglycemic rats treated metformin as refference standard metformin) and treatment ethanol extract Echinometra mathaei dose 100 mg/kgBW, 200 mg/kgBW 400 mg/kgBW). Alloxan monohidrat 120 mg/KgBW used diabetogen agent. parameters examined after 7 days treatment. observational data analyzed One Way ANOVA (P < 0.05) continued LSD. results showed all doses significantly reduced compared group. most effective reducing mg / kgBW.
 Key word: induced, mathaei, 70%, hiperglycemia, marine product.